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American Society of Clinical Oncology Summary: A new analysis of dietary patterns among more thanAmericans suggests that frequent consumption of citrus -- namely whole grapefruit and orange juice -- may be associated with an increased risk of melanoma. Melanoma risk was 36 percent higher psoriasis lifestyle factors people who consumed citrus fruit or juice at least 1.
Share: FULL STORY A new analysis of dietary patterns among more thanAmericans suggests that frequent consumption of citrus -- namely whole grapefruit and orange juice -- may be associated with an increased risk of melanoma.
The study researchers argue that the apparent link between melanoma and citrus fruit consumption may be due to high levels of substances called furocoumarins found in citrus fruits. Prior research showed that furocoumarins make the skin more sensitive to sunlight, including to melanoma-causing ultraviolet UV rays.
Questionnaires were mailed at various intervals to assess dietary intake at least every four years and collect information on medical history and lifestyle factors every two years.
For the purposes of the survey, a serving of citrus fruit was defined as the equivalent of half of a grapefruit, one orange, or a small 6 oz glass of grapefruit or orange juice.
People with a history of cancer were excluded from the analysis. Over a follow-up period of up to 26 years, 1, 1.
Higher overall citrus fruit consumption the total number psoriasis lifestyle factors servings of whole grapefruit, whole oranges, and juices from those fruits japanese pikkelysömör krém associated with increased risk of malignant melanoma in both men and women. The association was strongest for grapefruit, followed by orange juice.
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Conversely, and interestingly, consuming either grapefruit juice or whole oranges was not associated with melanoma risk. Furthermore, the association between eating whole grapefruit and melanoma was independent of age and lifestyle factors, such as physical activity, cigarette smoking, alcohol and coffee intake, and use of vitamin C supplements.
However, the association was more apparent among those who were more susceptible to sunburn as a child or adolescent and those who spent more time in direct sunlight.
The authors speculate that the levels of furocoumarins may be higher in whole fruit than in processed juices. They suspect that the significant effect of orange juice on melanoma risk can be explained by its consumption level, which was several times higher than any other citrus product. There was no significant association between other furocoumarin-rich foods, such as carrots and celery, and melanoma risk.
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Further research into furocoumarin levels in citrus fruit and juice and participants' blood samples is planned to confirm these hypotheses. According to the authors, this is the first large study to investigate the link between dietary psoriasis lifestyle factors and melanoma risk. Prior research has shown that tanning lotions containing psoralens a group of naturally occurring furocoumarins increase the risk for melanoma.
Long-term use of oral psoralen as part of therapy for severe psoriasis can also increase risk of melanoma.
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However, she identified several important limitations of the study worth noting. This includes a study population of health professionals, which is not representative of the general population. According to Dr. Berwick, this is a potentially important study because citrus consumption is widely promoted as an important psoriasis lifestyle factors of the diet. Citrus has demonstrated benefit for coronary heart disease, cancer prevention, and overall health effects.
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There is clearly a need for replication of the study findings in a different population prior to modifying current dietary advice to the public. Note: Content may be edited for style and length.
Journal Reference: S. Wu, J. Han, D. Feskanich, E. Cho, M. Stampfer, W. Willett, A.